Research over the past couple of decades has revealed that oxidative stress and inflammation underly most chronic diseases of aging – including cancer. While there are many factors that contribute to this, including diet, lifestyle, genetics, and environmental exposures, there is mounting evidence that certain phytonutrients called bioactives can help. These bioactives are components of foods that aren’t actually nutrients but have biological effects, and act primarily through talking to genes and influencing gene expression. This is called nutrigenomics.

While each of these ingredients has been shown to help various aspects of cellular health that underlie many age-related diseases including cancer, they are even more effective when taken in combination. This is because they target multiple genes involved in different aspects of our biochemistry and biology. We call this nutrigenomic synergy, and it is the cutting edge of supplement science.


• Grape Seed Extract: derived from grape seeds, this extract is high in potent antioxidant compounds including multiple different phenols, proanthocyanidins and flavonoids. Through their impact on many different genes, they can support healthy antioxidant and immune responses and may be beneficial in protecting DNA, brain health, hormonal balance, collagen, cardiovascular health and cholesterol metabolism.

• Green Tea Leaf Extract: this extract from green tea leaves contains ECGC, or epigallocatechin-3-gallate – the primary ingredient behind green tea’s many health-promoting effects. As a type of antioxidant called polyphenols, it targets genes in both antioxidant and anti-inflammatory systems and can support many cellular functions including DNA protection and repair, detoxification, hormonal balance, blood glucose and insulin, fat metabolism, immune response, and brain health.

• Apigenin: found in a variety of plants including parsley, chamomile, celery, spinach, artichokes and oregano, this flavone is a powerful antioxidant that impacts genes in multiple systems, including immune response, cognitive functioning, and glucose regulation in addition to key cell growth pathways involved in cancer.

• Resveratrol: two forms of this well-known antioxidant provide a full spectrum of protection. The trans-resveratrol is one of the best-studied components of the Japanese knotweed plant (Polygonum cuspidatum). The methylated form called pterostilbene is shown to have enhanced absorption, and works with trans-resveratrol to activate the “master” antioxidant gene to produce Nrf2 which turns on the body’s own antioxidant system.

• Lutein: this carotenoid is an antioxidant shown to support health of the retina and protect against macular degeneration and cataract formation. It also may support healthy skin by reducing skin damage related to sun exposure. It works best in combination with other carotenoids.

• Astaxanthin: derived from microalgae, astaxanthin is more potent than other carotenoids. It supports the body’s healthy antioxidant and immune responses by targeting key genes including the “master” antioxidant and immune response genes Nrf2 and NF-KB. With special focus on its ability to protect cell membranes against lipid oxidation, it supports skin integrity, brain health, glucose metabolism and cardiovascular health.

• Zeaxanthin: one of several carotenoids shown to support health of the retina and protect against macular degeneration and cataract formation, it also has systemic antioxidant activity and supports a healthy immune response in other tissues through increasing the production of the “master” antioxidant Nrf2. It may play a key role in supporting healthy HDL and LDL levels, protecting against liver disease and DNA damage.

• Quercetin: one of the most potent bioactive compounds, it is derived from the flower of the Sophora japonica plant. Quercetin works on supporting both the antioxidant and immune systems. Because it acts on the “master” genes that controls these systems, known as Nrf2 and NF-KB, it is a key ingredient to support cellular and DNA health.

• Citrus bioflavonoids: These potent antioxidants also promote a healthy immune response, and have been shown to affect a wide number of biological processes including glucose and lipid metabolism, including in adipose cells. Studies suggest that citrus bioflavonoids may support cardiovascular health, blood sugar regulation, and weight management.

• Alpha-lipoic acid: an antioxidant that plays a key role in mitochondrial metabolism, it also enhances nitric oxide production to provide cardiovascular support. It also inhibits activation of NF-KB, the “master” gene involved in chronic inflammation, and has been shown to support healthy glucose metabolism. It also helps to recycle other antioxidants including vitamins E and C, glutathione and coenzyme Q10.

• Glucoraphanin is a potent antioxidant found in broccoli, and the active compound in the TruBroc extract. It is converted in the body into sulphoraphane, which supports antioxidant and detoxification processes. It is also associated with energy, skin, hormonal and immune benefits.

• Nicotinamide Mononucleotide (NMN) Nicotinamide adenine dinucleotide, or NAD+, is a critical molecule in mitochondria involved in energy production, and supports healthy cells by protecting mitochondria against damage and the aging effects of oxidative stress. Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR) are naturally-occurring forms of vitamin B3 that support NAD+ production, which naturally declines with age and lower levels are associated with many age-related diseases.

• Extramel SOD-B: Derived from melons, Extramel SOD-B contains superoxide dismutase, or SOD, a powerful front-line antioxidant found in every cell, including in mitochondria. Decreased activity is associated with dysfunction of almost every biological system and a variety of diseases, including stress. As it also declines with age, lower levels are implicated in many age-related health issues including premature aging, neurodegenerative diseases, cancer, and diabetes. In addition to supporting a healthy antioxidant response, SOD may also improve stress and stress-related fatigue.

• ETAS 50: Derived from the tough ends of asparagus stalks, this unique molecule targets several genes involved in the immune response including NF-KB, as well as activating a key component involved in cellular aging called health shock protein 70 (HSP70). HSP70 repairs damaged cells, supports and healthy immune response, and has antioxidant properties as well. It may support healthy sleep, cognitive function, skin protection from UV light, and a healthy stress response.

• Mito-PQQ: found naturally in a variety of foods, pyrroloquinoline quinone, or PQQ, is an enzyme cofactor that helps to stimulate the synthesis of new mitochondria, in addition to its antioxidant effects. Chronic oxidative stress can result in fewer healthy mitochondria as we age. As mitochondria are critical for healthy cell functioning and production of energy, Mito-PQQ may help support efficient metabolism, physical energy, cognitive function, and healthy aging.



Written by: Dr. Roberta Kline

The primary culprits in aging are oxidative stress and impaired mitochondria. COMPLEX CELLULAR SUPPORT, (part of our NUTRIGENOMICS PLUS series) is a whole-body restorative strategy- optimizing the very heart of our body's energy production. NUTRIGENOMICS PLUS was created to be a powerful custom designed nutritional supplement for adults, recommended for anyone over 18 years old who wants to support their overall health*. It is not designed for any specific illness or disease, but instead offers a wide array of nutraceuticals including focused antioxidants, anti-inflammatories and mitochondrial support for overall wellness and longevity.

The custom designed formula avoids high doses of ingredients to achieve its effects. Instead it focuses on the synergy of multiple compounds that enables similar benefits with smaller doses. This minimizes the contraindications and potential interactions with other supplements or medications. Decades of research and clinical reviews in the science of formulating has led to our formulation of NUTRIGENOMICS PLUS as a safe and supportive supplement for anyone currently taking multivitamins or those seeking to optimize their cellular performance.*

INTRODUCTION: Food in its most natural, unprocessed form is the best source of nutrition. But our modern way of growing and processing foods has led to much of what we eat to be nutritionally deficient. This has led to the need for supplementation to fill the gaps between what our bodies need and what we get in our diets. The word Nutraceutical was originally derived from a combination of the words “nutrition” and “pharmaceutical”, and a similar term bioceutical has more recently been introduced. A Nutraceutical or Bioceutical product contains compounds derived from food sources that have cellular or physiological effects and are typically in purified or concentrated form.

Often promoted as alternatives to pharmaceuticals, they are used for health benefits and are in the same category as dietary supplements and food additives by the FDA, under the authority of the Federal Food, Drug, and Cosmetic Act. Because they are widely under-regulated, every brand and formulation varies in strength and quality of ingredients- ranging in effects and wellness success.

A modern movement in functional healing called PERSONALIZED NUTRITION is a health strategy allowing us to better analyze and meet our body's needs. Arriving at more effective solutions means QUESTIONING WHAT'S OUT THERE, THEN undergoing more educated research as part of making better decisions.

STRATEGIC INGREDIENTS: What we have assembled with these top ingredients is a complete wellness supplement! It was not meant to address any one specific disease or a specific chronic health issue. It is something that would be safe for everybody to take for overall wellness. What I looked at are the key underlying root causes to support wellness. This means hand selecting antioxidants t support immune function and mitochondrial function. We know that many of these bioactives are the kinds of ingredients that work better in combination. There's a synergy that happens with them that is missing when you use single ingredients. Not to say that single ingredients don't have their value, but for this purpose, you want a synergistic blend of a variety of different nutraceuticals and bioactives that each target various aspects of these systems. This means that looking at the function of the product, I aimed to make sure that I have enough of each ingredient to have some effect, but not a therapeutic treatment dosing.


DR. ROBERTA KLINE is a board-certified ObGyn physician, Functional Genomics and Integrative Personalized Medicine expert and clinical researcher. Dr. Kline’s passion for scientifically validating findings and interventions extends beyond her work with her patients. Awarded for her excellence in clinical research, she also has extensive experience leading genomic testing research. More recently, Dr. Kline has been involved in creating protocols for validating and evaluating the efficacy of health technology and devices utilizing functional genomic and metabolic biochemical testing.